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KMID : 0616120080390030223
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 3 p.223 ~ p.227
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Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II)
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Lee Yun-Mi
Kim Young-Sook
Kim Jong-Min
Jang Dae-Sik
Kim Joo-Hwan
Yoo Jeong-Lim
Kim Jin-Sook
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Abstract
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Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines < exhibited an inhibitory activity against AGEs formation compared with anminoguanidine . Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.
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KEYWORD
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Advanced glycation end products (AGEs), diabetic complications, herbal medicines
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